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Creatine synthesis is regulated primarily through: (1) changes in expression of renal arginine: glycine amidinotransferase in both rats and humans

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10.1097/qad.0000000000001222 [DOI] [PMC free article] [PubMed] [Google Scholar] Hamanishi T., Furuta H., Kato H., Doi A., Tamai M., Shimomura H., et al

This overlap with ME/CFS research has become increasingly apparent, reinforcing the mechanism of post-exertional malaise

9,13 In children less than 12 years old, an attempt should be made to terminate the episode by giving 0.05 to 0.1 mg/kg IV lorazepam (maximum [max] 4 mg) and 0.3 to 0.4 mg/kg IV ondansetron (max 0.45 mg/kg/day)