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Gliotoxin can also inhibit tumor cell proliferation and viral RNA replication and induce apoptosis of hepatic stellate cells as well as hinder the expression of nuclear factor-kappa B (NF-B), exhibiting promising prospects in the fields of antitumor, antivirus, and anti-liver fibrosis and immunosuppression during organ transplantation [6]

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Furthermore, we observed that ACTL6A suppression sensitized GC cells to H 2 O 2 , erastin, and buthionine sulfoximine (BSO), which are ferroptosis inducers, but not to compounds (e.g., etoposide and doxorubicin) that inhibit cell growth through other mechanisms (Fig