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Process Biochem 42(3):454458 Bachhawat AK, Ganguli D, Kaur J, Kasturia N, Thakur A, Kaur H et al Glutathione production in yeast

Dietary folate deficiencies and drugs that interfere with folate metabolism, eg, methotrexate, an anti-carcinogenic agent that inhibits dihydrofolate reductase, and nitrous dioxide (N 2 O), an anesthetic gas that inhibits methionine synthase activity, lead to accumulations and cellular effluxes of homocysteine, causing increases in circulating homocysteine levels (Ueland and Refsum, 1989)

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We have previously developed a mathematical model of sex differences and the effects of estradiol in one-carbon metabolism [11,22]