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Moreover, inflammatory form as pyroptosis, of programmed cell death, has been implicated in liver diseases, where caspase-1 activation triggers membrane rupture, inflammatory cytokine release, and exacerbated tissue damage 4 Furthermore, inflammasomes, including the NLRP3 ((NOD-, LRR-, and pyrin domain-comprising protein 3), have been concerned in liver diseases, where activation of this complex triggers caspase-1 activation, promoting pyroptosis and inflammatory cytokines release such as IL-1 and IL-18, further exacerbating liver damage 5

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Metformin and omega-3 fish oil elicit anti-inflammatory effects via modulation of some dysregulated micro RNAs expression and signaling pathways in experimental induced arthritis

Subsequently, the qualified interaction modes with the minimum ligand conformer energy and protein docking score were used to construct optimal VHL-DeTYR-3-TYR ternary complex 43 through pairwise RMSD analysis 44 (Supplementary Fig