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Extensive research on the Nrf2 signalling pathway has revealed its involvement in various chronic diseases, including RA, where disruptions in the Nrf2 signalling pathway have been observed [19]

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Therefore, modulation of endogenous LOX activity or expression selectively has been demonstrated effective for promotion of tensile properties and cross-linking of cartilage, as well as phenotypic control of chondrocytes, which appears as promising clinically applicable approaches of regenerative medicine and tissue engineering (Makris et al., 2014

Instituto Politcnico Nacional, 195