References Rossignol DA, Frye RE
Its possible that hormone imbalances are at play
This does not definitively establish that tirzepatide cannot affect sleep in some individuals, as clinical trials may not capture all potential effects, particularly those that occur at low frequencies or emerge during longer-term use
Abbreviations ACPs: Anticancer peptides PDCs: Peptidedrug conjugates HNP-1: Human neutrophil peptide LfcinB: Lactoferrin GHRH: Growth hormone-releasing hormone STAT3: Signal transducer and activator of transcription 3 GSH: Glutathione ADCs: Antibodydrug conjugates mAb: Monoclonal antibody USFDA: US Food and Drug Administration BBB: Bloodbrain barrier SORT1: Sortilin 1 DTX: Docetaxel NSCLC: Non-small cell lung cancer HDM-2: Human double minute 2 Apaf-1: Apoptotic protease-activating factor-1 ROS: Reactive oxygen species TP53: Tumor protein 53 AIF: Apoptosis-inducing factor EndoG: Endonuclease G PLP2: Proteolipid protein 2 DAMPs: Damage-associated molecular patterns HMGB1: High-mobility group protein B1 VEGF: Vascular endothelial growth factor PDGF: Platelet-derived growth factor FGF: Fibroblast growth factor CK2: Casein kinase 2 MMP: Matrix metalloproteinase VEGF-A: Vascular endothelial growth factor ALA-A2: Alpha-lactalbumin-A2 IC50: Half maximal inhibitory concentration DCs: Dendritic cells Treg: Regulatory T cell IFN-: Interferon-gamma HLA: Human leukocyte antigen IL-2: Interleukin-2 PEG: Polyethylene glycol MOMP: Mitochondrial outer membrane permeabilization Cyt c: Cytochrome c AIF: Apoptotic-inducing factor mPTP: Mitochondrial permeability transition pore IMM: Inner mitochondria membrane VDAC: Voltage-dependent anion channels MTD: Mitochondrial-targeting domain UCPVax: Universal cancer peptide-based vaccine RhoC: Ras homolog gene family member C SSRT2: Somatostatin receptor-2 References Abdelmageed MI, Abdelmoneim AH, Mustafa MI, Elfadol NM, Murshed NS, Shantier SW, Makhawi AM (2020) Design of a multiepitope-based peptide vaccine against the E protein of human COVID-19: an immunoinformatics approach
[DOI] [PubMed] [Google Scholar] 109.Bujalska I.J., Draper N., Michailidou Z., Tomlinson J.W., White P.C., Chapman K.E., a Walker E., Stewart P.M
