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Generation of cellular ROS production, decrease in nitric oxide bioavailability, and activation of enzymes like NADPH oxidase, and many signaling factors induce oxidative stress followed by breakdown of redox balance with consequential development of physiological and metabolic disorders, including endothelial dysfunction, inflammation and increasing concentration of VSMCs

Development of a functional salivary gland tissue chip with potential for high-content drug screening

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Increased levels of nitric oxide can lead to lower blood pressure