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Pathogenic, glycolytic PD-1 + B cells accumulate in the hypoxic RA joint

Considering that the human APOE isoform further regulates A clearance efficiency, and that sex and age modulate APOE-related AD risk via hormonal and aging factors (Cacciaglia et al., 2022), APOE-4 is associated with more severe cognitive decline and increased AD risk, particularly in individuals aged 7080 (Cacciaglia et al., 2022)

doi: 10.3390/ijms22095010 6 ArodinL.Miranda-VizueteA.SwobodaP.FernandesA