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This decline has been associated in research with disrupted circadian signaling and diminished antioxidant capacity, as melatonin is both a direct free radical scavenger and a regulator of antioxidant enzyme expression

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Similarly, melatonin, procyanidin B2, quercetin, and spermidine have been associated with increased expression of LC3-II and Beclin-1, suggesting enhanced autophagic flux and improved granulosa cells viability under oxidative stress conditions (Zhang et al., 2016

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Degranulated mast cells were identified by the reduced presence of cytoplasmatic granules