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To demonstrate that suppression of p70S6K protein and pNPM1 by RSL3 is GPX4 inhibition-specific in PTC cells, we treated K1 cells with RSL3 (3 M) in the presence of ferrostatin-1 (5 M), an effective inhibitor of ferroptosis and analyzed by Western blotting

Given the absence of human trials, the regulatory status, the quality concerns with research peptide vendors, and the cancer biology questions around c-Met activation, the case for Dihexa is weak

Dibble SL, Luce J, Cooper BA, Israel J, Cohen M, Nussey B, Rugo H

For a 50mg vial, adding 2ml of bacteriostatic water creates a concentration of 25mg per ml, or 2.5mg per 0.1ml

Like with tirzepatide, this separation suggests combination potential, though no clinical trials have evaluated this pairing