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For the primary efficacy analysis of actimetry and home diary outcomes, the outcome values were calculated using the measures performed during the planned weeks of assessment (the first and last week of each treatment period) without deviations from the target oral l-dopa dose (that is, a week when the patient did not receive the oral optimized l-dopa dose determined in phase 1 of the DIVE-1 study)

Ethics statement The work was approved by the Medical Research Ethics Committee Mansoura Faculty of Veterinary Medicine (Code number: R/141) in accordance with NIH and EU standards for animal care

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Macrophage polarization and meta-inflammation