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While NAD therapy shows promise in several areas, we emphasize that more clinical research is needed to fully understand its benefits, risks, and best practices

Direct vs

Untreated vitamin B12 deficiency may result in subacute combined degeneration of spinal cord or irreversible neuropathy, which may occur in the absence of megaloblastic anaemia

B12 injections offer a direct and efficient method of addressing deficiencies that may result from dietary factors, malabsorption issues, or specific medical conditions

Therefore, this study aimed to compare two intranasal vitamin B12 dosage regimens (with and without loading dose) in elderly patients deficient in vitamin B12, focusing on vitamin B12 levels and three biomarkers indicative of deficiency: holotranscobalamin, methylmalonic acid, and total homocysteine