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When Yuyang Liu, a graduate student in his lab and first author of the study, compared SLC25A39s structure against others in the SLC family of transporters in the AlphaFold protein structure database, Liu spotted a unique extra loop in the protein

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C., et al., Crystalline alpha-lipoic acid

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It is of interest from an evolutionary standpoint, that two key enzymes in this family, hydroperoxide lyase and divinylether synthase, differ only in a few amino acid residues, and there are other close structural relationships between enzymes of the CYP74 family