For instance, calcium oxalate and uric acid stones are best addressed by raising urine pH while calcium phosphate stones require lowering urine pH (Xu 2013
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Interestingly, the HLA association suggests a relationship to GD specifically, since it has to do with the presentation of specific antigen epitopes, whereas the CTLA-4 polymorphism appears to be a general phenomenon, allowing one population group to have augmented lymphocyte proliferation, but is not specifically related to thyroid disease
Konofagou EE, Provost J