While the medication helps to regulate appetite and increase feelings of fullness, your diet, movement and overall health play a vital role in achieving a healthy body weight
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These injections are not included in NICE guidelines for weight management, which instead emphasise evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, and in appropriate cases, pharmacological treatments (such as orlistat or semaglutide) or bariatric surgery
Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities
However, it can be added to some food products and is available as an injection or oral supplement