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How MSCs May Influence Autism Biology In preclinical models, MSC therapy has been associated with: Reduced neuroinflammation Decreased microglial activation Increased production of neurotrophic factors Enhanced synaptic plasticity Improved neuronal survival In mouse models of autism, MSC treatment has been linked to improvements in social interaction and reductions in repetitive behaviors

Psychiatric conditions, such as major depressive disorder (MDD) and somatic symptom disorder, were evaluated owing to the patients depression, cognitive disturbances, and persistent musculoskeletal pain [25]