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The Critical Caveats This is where my concerns become most significant

doi: 10.1001/jamanetworkopen.2024.17440 116 OhiraH.TsutsuiW.FujiokaY

Clinicians therefore need to know not only the half-life of the drug that they are prescribing but also what the half-life might be given the presence of one or more of these factors in the patient to whom the drug is being prescribed