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Of note, to reduce the generation of mitochondrial ROS or to increase the scavenge of ROS similarly attenuate mitochondrial oxidative stress and kidney injury ( 3.2.1 Keap1-Nrf2-ARE signaling pathway activators 3.2.1.1 Epigallocatechin 3-Gallate (EGCG) EGCG, a bioactive constituent extracted from green tea, is widely investigated in various diseases, such as cardiovascular diseases, diabetes and cancer

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Additionally, the interaction between NANOG, a gene associated with stem cells, and STAT3 increases MDR1 expression and the efflux of chemotherapeutic drugs, leading to chemoresistance development (70)