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Androgens, whether in excess (Hyperandrogenism) or in deficiency (Hypoandrogenism), cause oxidative stress by affecting immunological responses, fostering chronic inflammation, causing mitochondrial dysfunction, and causing oxidative damage in reproductive organs, thereby affecting fertility and reproductive health ( Table 1 )

JAMA 2002 Apr 10

Although the diclofenac loaded micelle has been ratified for rheumatism treatment, diclofenac micelles are still unstable and rapidly cleared in the blood

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