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Motivation is provided by inflammatory signals from the injury

(8) Long-term vitamin B12 deficiency can cause permanent nerve damage and neurological symptoms

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Sublingual administration, which bypasses the gastrointestinal tract, appears to be equally effective as IM injections while being less invasive and more cost-efficientparticularly in patients with atrophic gastritis, post-gastrectomy status, or conditions that impair intrinsic factor-mediated absorption, where long-term intervention is often required