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If taking higher doses, it is highly recommended to split the administration (e.g., one dose in the morning and one in the early afternoon) to maintain steady blood levels of the active compounds throughout the day

Additional information Peer review information Nature Communications thanks Lizeng Gaoand the other anonymous reviewer(s) for their contribution to the peer review of this work

doi: 10.1152/physiologyonline.2001.16.3.118

However, we previously reported intracellular levels of these mediators in relation to GPX4 activity (7) that are likely similarly altered here

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