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Despite not fully comprehending the mechanisms underlying these disorders in chronic kidney disease (CKD), the robust association among homocysteine, cysteine, S-adenosylmethionine, S-adenosylhomocysteine, and plasma creatinine levels, as well as the glomerular filtration rate (GFR), indicated that these compounds were excreted in the urine

Measuring homocysteine is one of the most useful ways to assess methylation efficiency and identify nutritional imbalances that may increase long term disease risk

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