Anthraquinone modifications can significantly upregulate the expression of glucose-regulated protein 78, activate transcription factor 4, and downregulate the expression of the essential ferroptosis protein GPX4
In our study, intracellular ROS levels and ferrous ion concentrations, which are key facilitators of the Fenton reaction, were significantly elevated following cystine treatment
Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, et al
Pickart & Margolina's 2018 review reported modulation of approximately 4,000 human genes in cultured cells [16]
Effects of recurrent intra-articular corticosteroid injections for osteoarthritis at 3 months and beyond: a systematic review and meta-analysis in comparison to other injectables