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The schistosome oligosaccharide lacto-n-neotetraose expands Gr1 + cells that secrete anti-inflammatory cytokines and inhibit proliferation of naive CD4 + cells: a potential mechanism for immune polarization in helminth infections

In some embodiments, the otic formulation or composition comprises between about 0.10% to about 1% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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