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Strength points and limitations Based on our knowledge, this is the most updated meta-analysis on this topic, including all available evidence based on our inclusion criteria of including only controlled studies, either RCTs or controlled observational studies, to reach the highest accessible quality of evidence from the available evidence found in the literature

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Large doses of folic acid may also partially mask or worsen vitamin B deficiency by correcting anemia while allowing neurological damage to progress

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According to epa.gov: T he Total Coliform Rule (TCR), a National Primary Drinking Water Regulation (NPDWR), was published in 1989 and became effective in 1990