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Diet and exercise remain the foundation every other intervention is built on, and they meaningfully improve obesity-related conditions such as hypertension and type 2 diabetes

Several neurotransmitters (serotonin, noradrenaline, dopamine, and histamine), peptides (neuromedin U, urocortin, bombesin, amylin, galanin), hormones (thyroid hormone, growth hormone) and cytokines (ciliary neurotrophic factor) also play a role in modulating feeding behavior and energy expenditure [5-10]

This nutrient supports nerve function, red blood cell production, and DNA synthesis

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Treatment for confirmed B12 deficiency includes oral cyanocobalamin for dietary causes or intramuscular hydroxocobalamin for malabsorption or neurological involvement, following NHS and BNF guidance