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The kidney and cardiovascular effects of current and next-generation incretin and metabolic hormone therapies remain an area of active investigation

L. I. Fedoreyeva, I. I. Kireev, V. Kh. Khavinson, and B. F. Vanyushin, Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA, Pleiades Publishing Ltd, Nov. 2011. doi: 10.1134/s0006297911110022

One major obstacle is that determining the quantitative contribution of modulating lactate balance to therapeutic efficacy remains challenging

Basu RK, Wheeler DS (2013) Kidney-lung cross-talk and acute kidney injury

The data collected were deconvoluted using SVD, fitting the data to the linear two-step irreversible model shown