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Without long-term safety data, its impossible to fully assess risks or unintended consequences over months or years
In some embodiments, the lipid-based drug delivery formulation or composition comprises about 25% v/v or less of any one or more chemical penetration enhancer(s), most preferably from about 2% to 15% v/v, although the exact formulation or composition will vary depending on the presence and amounts of excipients, preservatives, water, pH modulators, and the like included therein
[DOI] [PubMed] [Google Scholar] 53.Baraldo S, Faffe DS, Moore PE, Whitehead T, McKenna M, Silverman ES, et al
This desensitisation phenomenon is an important consideration for studies spanning weeks or months, and researchers should design protocols to account for potential tolerance development
R.et al (1999)
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