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Eight weeks of aerobic exercise significantly activated the System Xc /GPx4 signaling pathway in the prefrontal cortex of APPswe/PS1dE9 transgenic AD mice, up-regulated FTL and BACE1 expression, significantly downregulated 4-HNE levels, inhibited oxidative stress, lipid peroxidation, and ferroptosis, reduced A positivity, alleviated neuronal morphological abnormalities, and improved learning and memory functions in AD mice (Li et al., 2024a)

Oxidative stress markers8-OHdG and PGF2were significantly reduced at Weeks 8 and 12, confirming that improved glutathione levels correlated with reduced oxidative damage

Nutrients 11(4):719

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Acetate mediates a microbiome-brain--cell axis to promote metabolic syndrome