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doi:10.1007/s00394-021-02665-2 Kato N, Kimoto A, Zhang P, et al

Tirzepatide may contribute to anxiety through several indirect pathways

Overactivation of MR in all of these cells by both aldosterone-dependent and -independent pathways promoted the expression of profibrotic (such as TGF-1, PAI-1, CTGF, collagen I and III, fibronectin) and proinflammatory (NFB, IL-1, and TNF-) genes contributing to development of fibrosis and progression of CKD [185, 187,188,189,190]

[DOI] [PubMed] [Google Scholar] Sun et al

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