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Possible factors include disease stage, lesion location, inflammatory profile, and metabolic status, but none of this has been studied

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The damaged intestinal villi also lose their ability to produce Diamine Oxidase (DAO), the primary enzyme responsible for breaking down dietary histamine

First, while our findings remained largely unchanged after excluding participants with comorbid schizophrenia and intellectual disability, and no significant effects of comorbid ADHD or depression were observed on the neurometabolite measures examined, we cannot entirely rule out the potential influence of comorbidities on our results

Heij L, Niesters M, Swartjes M, et al