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The typical pattern of doseresponse effects of Rhodiola rosea extracts was observed on the duration of thiopental-induced sleep in mice, ranging from stimulation at low doses (10 mg/kg), where the sleep period was reduced by 12.5 times, to sedation at high doses (500 mg/kg), where the sleep period was increased 3-fold [88]

It has a high affinity for Copper(II) and so is present in two forms, GHK and GHK-Cu ( Figure 1a,1b ) [1]