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Problems arise only when its production becomes imbalanced

Turkish Neurosurg 30:899906 Zang Y-N, Si-Zheng W, Qin Y, Zhang J-R, Li-Bo Z, Xiao-Ling W (2019) Population pharmacokinetic study of delayed methotrexate excretion in children with acute lymphoblastic leukemia

Following the two week period, researchers may continue administering a maintenance dose of 1mg/daily, if necessary to achieve full or near-full recovery among test subjects

Regular follow-up should include assessment of weight loss trajectory, tolerability, medication adherence, and renal function if significant GI symptoms occur

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells