All authors had full access to study data, contributed to the drafting and revision of the manuscript and approved the manuscript for submission
This is an essential point to consider when assessing the inter-variability in the response to metformin, as it helps to understand the gut microbiotas contribution to the unresponsiveness
suggested that HIF-1 is a crucial regulatory factor inducing breast cancer metastatic niche forming through activation of several elements of the lysyl oxidase (LOX) family, which catalyze collagen cross-linking in the lungs before BMDC recruitment (98)
Receptor Signalling Activates TGF-beta, VEGF, and FGF pathways - coordinating tissue regeneration, vascularisation, and the inflammatory resolution cascade
In conditions like Long COVID and ME/CFS, the immune system is often stuck in a hyperactive, dysregulated state, constantly churning out inflammatory cytokines