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The Ca 2+ entry mechanisms in ECs play important roles in this process, as evidenced by the observations that removal of extracellular Ca 2+ or inhibition of CaM suppresses agonist-induced NO production (Forstermann et al., 1991

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Concurrently, novel investigations are exploring targeted microbial therapies, including probiotics, prebiotics, and fecal microbiota transplantation (FMT), to optimize therapeutic outcomes for PCOS patients ( Figure 4 , Table 2 )

It is particularly beneficial for individuals experiencing fatigue, pigmentation issues, or chronic conditions linked to oxidative stress such as asthma, COPD, or neurodegenerative disorders

However, many challenges remain in the current research on nanoparticle delivery systems to alleviate radiation-induced inflammation and injury, especially in terms of unsatisfactory biocompatibility, low drug delivery rates, and lack of long-term stability