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(145) demonstrated that Cul5 deficiency elevates levels of chemokines such as CCL2, CCL5, CXCL5, and CXCL10, which are critical for monocyte recruitment (149, 150, 155158)

For instance, sulforaphane, a well-known Nrf2 activator has been widely used as both cancer preventive and anti-tumour agent [62,63]