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Recently, it has been illustrated that HCBP6 (FUNDC2), a mitochondrial outer membrane protein FUN14 structural domain containing 2, can interact with and destabilize SLC25A11, thereby affecting mGSH levels and regulating ferroptosis in the myocardium [61]

Therefore, pH 4.5 was identified as optimal for glutathione production in this strain

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PLoS ONE 8 , e54031 (2013)

The small thiol present in highest concentration in the cytoplasm is glutathione (GSH), a tripeptide glycine-cysteine-glutamic acid (Figure 2): the SH group of its cysteine is extremely sensitive to oxidation, mainly by peroxides