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For instance, curcumin significantly reduced histopathological damage and improved general symptoms in experimental colitis, accompanied by increased the expression of Treg cells and decreased the expression of Th17 cells as well as increased the expression of anti-inflammatory cytokines such as IL-10 and decreased the expression of proinflammatory cytokines such as IL-17A, IL-1, IL-6, IL-33, CCL-2, IFN-, and TNF- [264, 266, 267]