Acta 510, 442449
ERAD as a central metabolic checkpoint: the Sel1L-HRD1 axis Among ERAD components, the Sel1L-HRD1 complex is highly conserved across species and has emerged as a central regulator of systemic metabolism, influencing diverse processes ranging from appetite control to lipid handling and insulin secretion
This pro-angiogenic effect involves stimulation of vascular endothelial growth factor (VEGF) production and activation of endothelial cells to proliferate, migrate, and form new capillary networks
Glutathione synthesis could be affected by fast CBS, in effect flooding and overwhelming GSS, or a GSS SNP could directly reduce its activity
Odisio, BC, Albuquerque, J, Lin, YM, Anderson, BM, OConnor, C, Rigaud, B, Briones-Dimayuga, M, Jones, AK, Fellman, B, Huang, SY, Kuban, JD, Metwalli, ZA, Sheth, RA, Habibollahi, P, Patel, MN, Shah, KY, Cox, V, Kang, HC, Morris, VK, Kopetz, S , Javle, M, Kaseb, A, Tzeng, CW, Cao, HT, Newhook, TE, Chun, YS, Vauthey, JN, Gupta, S, Paolucci, I, Brock, K