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Research increasingly suggests that this molecule may influence cell signaling pathways associated with inflammation, tissue remodeling, antioxidant defense, and even systemic regeneration

ApoE does so many different things that trying to target it in various traditional wayslike small-molecule approaches to interfere with one of its actions, for examplehasn't really worked, says Howard Fillit, cofounder and chief science officer at ADDF

It also serves as a substrate for various antioxidant enzymes, including glutathione peroxidase and glutathione reductase, which further amplify its protective effects

Below, we will briefly discuss what can be learned from this body of literature when designing pan-coronavirus vaccines

doi: 10.1016/s0047-6374(97)01897-6