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Specifically, EA treatment administered to rats for 60 min per day over 3 days significantly attenuated TBI-induced outcomes, including reduced infarct volume, grip strength loss, neuronal apoptosis (caspase-3 and TUNEL), microglia (Iba1), astrocyte (GFAP) activation, and TNF- expression

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These medications offer better results than current drugs like semaglutide and tirzepatide

LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al