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Most currently proposed biomarkers suffer from inadequate sensitivity and specificity, particularly in early-stage disease or asymptomatic patients

This creates a well-documented vicious cycle: stress increases histamine release, histamine amplifies nervous system reactivity (histamine H3 receptors modulate neurotransmitter release, and elevated brain histamine disrupts sleep, worsens anxiety, and heightens stress perception), which in turn drives more stress and further mast cell activation

Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in HIV-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials

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The anticonvulsant, phenytoin, has been shown to inhibit the intestinal absorption of folate, and several studies have associated decreased folate status with long-term use of the anticonvulsants, phenytoin, phenobarbital, and primidone (214)