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Blood Rev 2007;21:113-30

An increase in its concentration leads to an increase in cytosolic LCFA acyl CoAs, its esterification, formation of diacylglycerol, triglycerides, ceramide, and reactive oxygen species, all linked to insulin resistance.14,16,17 The excess of nonesterified fatty acids and the increased intracellular lipid content correlates with the presence of insulin resistance.18 The adipocyte is as a reservoir of fuel stored as triglycerides during caloric abundance for subsequent release during periods of caloric need

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D., Schwartz, M