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This tissue becomes a potent source of adipokines (e.g., leptin, resistin, visfatin), cytokines, and prostaglandins that act locally and systemically to exacerbate joint inflammation, cartilage catabolism, and pain perception (Wang M

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Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy

Evidence from multiple cohort studies demonstrates a substantially higher IBS incidence among COVID-19 survivors compared to control populations, with rates varying between 3-16% depending on methodology and diagnostic criteria