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Using current gnomAD data (v3.1.2 controls/biobank: 7,756 NFE, 9,102 AA individuals) to construct a population matching their CVS population (91% White as NFE, and 9% AA), none of the three SNPs achieve statistical significance by our reanalysis ( CNR1 rs806380, p = 0.33

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FIGURE 4 Cyclization of peptides is a strategy that can make peptides have a more stable conformation, enhancing the stability of enzymatic proteolysis and improving the permeability through biological barriers (Karami et al., 2023)

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