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Description

This reaction depends on the catalytic selenocysteine residue of GPX4, which is directly targeted and inactivated by ferroptosis inducers such as RSL3

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To demonstrate specificity of the effect, we sought to rescue the decreased mEPSC frequency by pretreating with pyroglutamate (PGA), the precursor of glutamate that is synthesized downstream of GGT, which is blocked by acivicin (Fig