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These initial clinical results support the concept of DPP1 inhibition as a potential therapeutic strategy across multiple inflammatory diseases that involve excessive NSP secretion or neutrophil dysregulation and hyperresponsiveness

[DOI] [PMC free article] [PubMed] [Google Scholar] 335.Benassayag C., Souski I., Mignot T.-M., Robert B., Hassid J., Duc-Goiran P., Mondon F., Rebourcet R., Dehennin L., Nunez E.-A., Ferr F

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10.1161/01.RES.0000119171.44657.45 Circ Res

We can indirectly assume ozone therapy influenced synthesis and release of cytokines (18,19) in such a way that a change from Th2 to Th1 (IL-2, IFNg) cytokine pattern occurs, or ozone therapy acted as Th2 cytokine inhibitor