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Another factor to take into account is that of senescence, which is the phenomenon of cell cycle arrest and the inhibition of cell proliferation, and is a hallmark of several age-related pathologies, including in the pathogenesis of some chronic wounds 168

In agreement with this hypothesis, both the ascorbate- deficient mutant vtc2-4 (which contains only 30% of the wild-type ascorbate) and the vtc2-4 dhar quadruple mutant showed comparable ascorbate accumulation in response to high light

In a subsequent experiment, rats were subjected to the same suspension protocol, but with daily release of the device for one hour, allowing normal cage movement during the dark phase

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Immunocompromised individuals or those on systemic retinoids may experience additive dryness and should initiate treatment with the Sensitive strength only under close monitoring