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Theres really good paper that I quoted in my book about mercury and its effect on the endocrine system

In the event DSIP does ultimately undergo clinical development, intranasal administration can ensure a higher degree of patient compliance by eliminating side effects and discomfort commonly associated with peptide injections

However, published data allows a directional comparison of the most common GI events: Adverse Event Retatrutide (12 mg) Semaglutide 2.4 mg (STEP trials) Tirzepatide 15 mg (SURMOUNT trials) Nausea ~46% ~44% ~31% Diarrhea ~33% ~30% ~23% Vomiting ~22% ~24% ~12% Constipation ~17% ~24% ~12% Important caveat: These numbers come from different trial populations and cannot be directly compared

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Several previous studies suggest that diet-derived factors offer potential for the prevention and therapy of a wide variety of cancers by altering various epigenetic modifications