Jun 5 2021;397(10290):2195-2211
New research shows that eating animal products causes animal sugars, such as Neu5Gc, to become attached to cells that line our hollow organs, like the stomach, causing the body to make antibodies against these sugars resulting in chronic inflammation and, therefore, impaired B12 absorption
Description 5-Amino-1MQ is positioned in research contexts as an NNMT (nicotinamide N-methyltransferase) pathway small molecule, not an NMN (nicotinamide mononucleotide) profile, with interpretation generally anchored to broader NNMT inhibition literature
But it has not been ruled out, and the FDA's briefing documents noted it as an uncharacterized risk requiring further investigation before any approval
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